SILVER SULFADIAZINE

Product Name : SILVER SULFADIAZINE

Molecular Formula :C10H9AgN4O2S

Molecular Weight : 357.14

Synonyms : (4-Amino-N-2- pyrimidinylbenzenesulfonamidato-NN,01)-silver, sulfadiazine silver, silver (I) sulfadiazine, 4-amino-N-(2-pyrimidinyl) benzenesulfonamide silver salt, dermazine, geben, silvadene

CAS No : 22199-08-2


Sr. No. Test Specifications
1 Description White to creamy-white, crystalline powder, odorless to having a slight odor
2 Solubility Freely soluble in 30% ammonium solution; slightly soluble in acetone; practically insoluble in alcohol, in chloroform and in ether. Decomposes in moderately strong mineral acids.
3 Identification
– By IR



– By HPLC

– By Chemically
The IR absorption spectrum of the test preparation should exhibit maxima at the same wavelength as that of a similar preparation of Silver Sulfadiazine working standard.

The principal peak in the chromatogram obtained with test solution should correspond to the peak in the chromatogram obtained with standard.

Meets the requirements.
4 Loss on drying (% w/w) Not more than 0.5
5 Limit of Nitrate (% w/w) Not more than 0.1
6 ORGANIC IMPURITIES
(BY HPLC)
Sulfanilic acid
2- Aminopyrimidine
Acetylsulfadiazine
Specified unidentified impurity
Individual unspecified impurity
Total impurities


Not more than 0.3 %
Not more than 0.3 %
Not more than 0.2 %
Not more than 0.15 %
Not more than 0.10 %
Not more than 0.5 %
7 Silver Content (% w/w) Between 29.3 and 30.5
8 Assay (By HPLC, % w/w)ODB Between 98.0 and 102.0
9 Particle Size (µm) Not more than 10% particle size is greater than 40 µm.
Average particle size: Not more than 10
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