DEXAMETHASONE

Product Name : DEXAMETHASONE

Molecular Formula : C22H29FO5

Molecular Weight : 392.46

Synonyms : Pregna-1,4-diene-3,20-dione, 9-Fluoro-11,17,21-tri-hydroxy-16-methyl-, (11ᵝ, 16α)-

CAS No :50-02-2


Sr. No. Test Specifications
1 Description White to practically white, odorless, crystalline powder.
2 Solubility Sparingly soluble in acetone, in alcohol, in dioxane and in methanol; slightly soluble in chloroform; very slightly soluble in ether; practically insoluble in water.
3 Identification

A) Infrared Absorption



B) Ultraviolet Absorption

The IR absorption spectrum of the test preparation should exhibit maxima at the same wavelength as that of a similar preparation of Dexamethasone working standard.
Absorptivities at 239 nm, on dried basis should not differ by more than 3.0%
4 Specific Rotation Between +72 ° and +80°
5 Loss on Drying Not more than 0.5% of its weight.
6 Residue on Ignition Not more than 0.2% from 250mg
7 Chromatographic Purity (By HPLC, % w/w)
• Individual Impurity
• Total Impurity
Not more than 1.0%
Not more than 2.0%
8 Assay (ODB) Between 97.0% and 102.0%
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